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Borrelia miyamotoi is a species of spiral bacteria that causes hard tick-borne relapsing fever (Borrelia miyamotoi disease) and is closely related to the bacteria that cause tick-borne relapsing fever. The disease is spread through tick bites, namely black-legged or deer ticks (Ixodes scapularis) and western black-legged ticks (Ixodes pacificus). These ticks are also known to transmit Lyme disease, babesiosis and ehrlichiosis.

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